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Heart & Vascular Research

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Heart & Vascular Care Backed by Innovative Research

For more than 20 years, WellSpan's Heart and Vascular Research Department, along with Wellspan Cardiology, Cardiac Surgery and Vascular Surgery, actively participate in clinical trials offered in the United States and Globally.

Our physicians also develop and conduct their own research exclusively for WellSpan patients. These research projects are supported by the Heart and Vascular Research Department from the early development stages through study completion, they conducted in the same ethical and safety standards as our large clinical trials.

To learn more about our Heart and Vascular Clinical trials, call us at (717) 851-4049.


How We Can Help

Researchers are identifying the newest and most effective treatment methods for cardiovascular disease through these carefully designed and conducted clinical trials. These advances help patients to live longer and better lives.

We are currently enrolling patients in the following trials. The NCT# specific identifying number assigned to a research trail when it is registered at the clinicaltrials.gov website. Learn more about these trials at ClinicalTrials.gov.


WellSpan York Hospital

DRUG STUDIES

NODE-303: A Phase 3, Multi-Center, Multi-National, Open Label, Safety Study of Etripamil Nasal Spray for Patients with Paroxysmal Supraventricular Tachycardia. [NCT #04072835]
Sponsor: Milestone Pharmaceuticals
Principal Investigator: Gregory Fazio, MD
The primary objective is to evaluate the safety of self-administered Etripamil nasal spray (NS) outside of the clinical setting for patients with a diagnosis of Paroxysmal Supraventricular Tachycardia

ORION HPS-4/TIMI 65/ORION-4: A Phase 3, double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease. [NCT #03705234]
Sponsor: University of Oxford
Principal Investigator: Kevin McCullum, MD
Testing whether a medicine called Inclisiran, which is given by subcutaneous injection every six months, can safely help to prevent heart attacks and strokes in patients who are known to have diseased arteries.

DAPA ACT HF-TI MI 68: A Phase 3b/4, Multicenter, Randomized, Double-Blind, Parallel Group, Placebo- Controlled Trial to Evaluate the Effect of In-Hospital Initiation of Dapagliflozin on Clinical Outcomes in Patients with Heart Failure with Reduced Ejection Fraction Who Have Been Stabilized During Hospitalization for Acute Heart Failure Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure - Thrombolysis in Myocardial Infarction 68. [NCT #04363697] *Currently eligible to hospitalized patients only
Sponsor: TIMI Study Group
Principal Investigator: Adnan Malik, MD, FACC
Primary objective is to assess the effect of in-hospital initiation of Dapagliflozin, as compared with placebo, on the clinical outcome of cardiovascular death or worsening heart failure in patients who have been stabilized during hospitalization for acute heart failure.

 

DEVICE STUDIES

ACURATE IDE: Transcatheter Replacement of Stenotic Aortic Valve through Implantation of ACURATE in Subjects InDicatEd for TAVR. [NCT #03173534]
Sponsor: Boston Scientific
Principal Investigator: James Harvey, MD, FACC
Study objective to evaluate safety and effectiveness of the ACURATEneo2TM Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR.

CATALYST: Clinical trial of atrial fibrillation patients comparing left atrial appendage occlusion therapy to non-vitamin K antagonist oral anticoagulants. [NCT #04226547] 
Sponsor: ABBOTT
Principal Investigator: Brian Schuler, MD
The objective of this trial is to evaluate the safety and effectiveness of the Amulet device compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term NOAC therapy.

CHAMPION-AF: WATCHMAN FLX versus NOAC for EMbolic ProtectION in the Management of Patients with Non-Valvular Atrial Fibrillation. [NCT #04394546]
Sponsor: Boston Scientific
Principal Investigator: Brian Schuler, MD
The primary objective of this study is to determine if left atrial appendage closure with the WATCHMAN FLX device is a reasonable alternative to non-vitamin K oral anticoagulants (NOACs) in patients with non-valvular atrial fibrillation.

FROzEN-AF: Safety and Effectiveness IDE trial for Boston Scientific’s Cryoballoon in the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation. [NCT #04133168]
Sub study: POLARX
Sponsor: Boston Scientific
Principal Investigator: Brian Schuler, MD
The objective of this study is to establish the safety and effectiveness of the Boston Scientific Cardiac Cryoablation System for treatment of symptomatic, drug refractory, recurrent, PAF.

SMART: SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial (SMART Trial)
Sponsor: Medtronic
Principal Investigator: Stewart Benton Jr, MD, FACC
The primary objectives of the trial are to demonstrate clinical non-inferiority and hemodynamic superiority of the Evolut PRO/PRO+ System when compared to subjects treated with the SAPIEN 3/3 Ultra System at 12 months post-procedure. [NCT #04722250]

 

REGISTRY

PROGRESS CTO: Multicenter Registry of Chronic Total Occlusion Interventions. [NCT #02061436]
Principal Investigator: Stewart Benton Jr, MD, FACC

Real- AF: Real-world Experience of Catheter Ablation from the treatment of Paroxysmal and Persistent Atrial Fibrillation using novel contact force technologies (REAL-AF) [NCT #04088071]
Sponsor: Heart Rhythm Clinical and Research Solutions, LLC (HRCRS)
Principal Investigator: Matthew Singleton, MD