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Staphylococcal Scalded Skin Syndrome

What is staphylococcal scalded skin syndrome?

Staphylococcal scalded skin syndrome is a response to a toxin produced by a staphylococcal infection and is characterized by peeling skin. The disease mostly affects infants, young children, and individuals with a depressed immune system or renal insufficiency. The disease can be life-threatening.

What are the signs and symptoms of staphylococcal scalded skin syndrome?

The following are the most common signs and symptoms of staphylococcal scalded skin syndrome. However, each child experiences symptoms differently. The disease usually begins with a fever and redness of the skin. Then, fluid-filled blisters may form. The blisters rupture very easily, leaving an area of moist skin. Other symptoms may include the following:

  • Red, painful areas around infection site

  • Blistering

  • Fever

  • Chills

  • Weakness

  • Fluid loss

  • Top layer of skin slips off with rubbing or gentle pressure (Nikolsky's sign)

After the top layer of skin has peeled off, the following symptoms may be present:

  • Fever

  • Chills

  • Weakness

  • Fluid loss through the open areas of moist skin

In newborns, the lesions are often found in the diaper area or around the umbilical cord. Older children more commonly have the lesions on their arms, legs, and trunk.

The symptoms of staphylococcal scalded skin syndrome may resemble other skin conditions. Always consult your child's doctor for a diagnosis.

How is staphylococcal scalded skin syndrome diagnosed?

In addition to a medical history and physical examination of your child, the diagnosis may be confirmed with a biopsy (taking a tissue sample to be examined under a microscope) and cultures of the skin and throat. Blood tests (CBC and electrolyte) can also help diagnose and manage this condition.

What is the treatment for staphylococcal scalded skin syndrome?

Treatment usually requires hospitalization, often in the burn unit of the hospital, because the risks of complications are similar to those of children with burns. Specific treatment for staphylococcal scalded skin syndrome will be determined by your child's doctor based on:

  • Your child's age, overall health, and medical history

  • Severity of the condition

  • Your child's tolerance of specific medications, procedures, or therapies

  • Expectations for the course of the condition

  • Your opinion or preference

Treatment may also include:

  • Antibiotics (oral or IV) for Staphylococcus to help fight the infection

  • Intravenous (IV) fluids to prevent dehydration

  • Supportive skin care measures (creams and ointments) to improve the skin's barrier function 

Staphylococcal Scalded Skin Syndrome - WellSpan Health

Online Medical Reviewer: Hanrahan, John, MD
Online Medical Reviewer: newMentor board-certified, academically affiliated clinician
© 2014 WellSpan Health. All Rights Reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

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