Menu   WellSpan Health

Health Library

Health Library

Other Arrangements: Rings and Inversions

What is an inversion?

There are other ways in which the structure of a chromosome can be altered. One example is called an "inversion." The term "inversion" is used when a chromosome breaks in two places, and the piece in-between turns upside down, and reattaches:

Genetic illustration demonstrating inversion

Some inversions are so common in the population that no additional testing is needed. If a rare or less common inversion is found in a child, the parents' chromosomes are studied to determine whether the inversion was inherited or not. If one parent has the inversion, then the doctor knows that the baby inherited the inversion from that parent. Since the parent is usually normal and healthy, this proves that the inversion did not cause any harm to the genes when the chromosome broke and turned upside down. (The parents' other relatives may also have inherited the inversion and should have the option of having their chromosomes studied). However, if the inversion is not present in one of the parents, there is a chance that some of the genetic material may have been lost or altered in the rearrangement. This could cause problems in the baby's development, including birth defects.

What is a ring chromosome?

Another example of a rearrangement is something called a "ring" chromosome. The term "ring" chromosome is used to describe a chromosome that has broken the ends off, and attached to form a circle or "ring:"

Genetic illustration, ring chromosome

Because the ends break off, genetic information is lost. Rings can also form without the ends breaking off, and the p arm and the q arm just "stick" together, without any apparent loss of genetic material. Sometimes, the rings (regardless of how they are formed) cause problems in the baby's development. This is because the ring interferes with cell division and can cause genes to not work properly because they are rearranged.

Ring chromosomes do not always cause health problems or delays in development. It depends on the size of the ring, how much genetic material was lost, and which chromosomes are involved. If a ring chromosome is found in a child, the parents' chromosomes are studied to determine whether the ring was inherited or not. If one parent has the ring chromosome, then the doctor knows that the baby inherited the ring from that parent. If the parent is normal and healthy, it is thought that the ring did not cause any harm to the genes when the ring chromosome formed. (The parents' other relatives may also have inherited the ring chromosome and should have the option of having their chromosomes studied). However, if the ring is not present in one of the parents, there is a chance that some of the genetic material may have been lost or altered in the rearrangement. This could cause problems in the baby's development, including birth defects.

Other Arrangements: Rings and Inversions - WellSpan Health

Online Medical Reviewer: Clark, Heather, MS, CGC
Online Medical Reviewer: newMentor board-certified, academically affiliated clinician
Last Review Date: 2013-06-23T00:00:00
Last Modified Date: 2013-06-25T00:00:00
Posting Date: 2008-11-30T00:00:00
Published Date: 2013-06-25T00:00:00
Last Review Date: 2007-03-30T00:00:00
© 2015 WellSpan Health. All Rights Reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

Are you sure you would like to cancel?

All information will be lost.

Yes No ×

About the provider search

This search will provide you with WellSpan Medical Group and Northern Lancaster County (Ephrata) Medical Group primary care physicians and specialists. If we don’t have a WellSpan Medical Group physician to meet your criteria, the search will expand to include community physicians who partner with WellSpan Medical Group physicians through the WellSpan Provider Network or provide care to patients on the Medical Staffs of WellSpan’s Hospitals.

×

Schedule Your Next Appointment Online with MyWellSpan

Use your MyWellSpan patient portal any time to view available appointments, and pick the date and time that best suits your schedule.

Go to MyWellSpan

New to this practice?

If you don't have a WellSpan primary care provider and would like to schedule a new patient appointment with a provider who is accepting patients, just log into your MyWellSpan account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to see the offices that are accepting new patients in relation to your zip code. If you are not enrolled in MyWellSpan, go to www.mywellspan.org, call 1-866-638-1842 or speak with a member of the staff at a participating facility to sign up. New patient scheduling not available at all practices/programs.

Already a patient at this practice?

If you already have a relationship with a WellSpan practice, simply log into your account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to schedule an appointment with any provider or practice that already counts you as a patient. Online scheduling varies by practice/program.

×