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Pheochromocytoma: An Adrenal Gland Tumor

What is a pheochromocytoma?

A pheochromocytoma is a rare type of tumor. It grows in the middle of an adrenal gland. Your body has 2 adrenal glands. They are found on top of each kidney. Each layer of these glands makes different hormones. The middle part of the adrenal glands makes epinephrine and norepinephrine. These hormones help keep your heart rate and blood pressure normal. A pheochromocytoma causes the adrenal glands to make too much of these hormones.

What causes pheochromocytoma?

It’s not known what causes this type of tumor.

Who is at risk for pheochromocytoma?

Pheochromocytomas happen equally in men and women. They often show up when you are in your 30s, 40s, or 50s.

If someone in your family has this type of tumor, you are more likely to get it. This tumor does not seem to be affected by environment, diet, or lifestyle. If you have this tumor, you should consider genetic testing.

What are the symptoms of pheochromocytoma?

The most common sign of a pheochromocytoma is high blood pressure. It can be constant or sometimes high. Sometimes the tumor can cause high blood pressure that can be life threatening. It is a very rare cause of high blood pressure. But it must be considered when medicine is not enough to control high blood pressure.

Other symptoms are less common. They can be brought on when you are under stress or when you change positions. The following are the most common symptoms. But each person may have symptoms in a different way.

  • Rapid pulse
  • Feeling that your heart is beating fast or fluttering (palpitations)
  • Headache
  • Nausea
  • Vomiting
  • Clammy skin
  • Tremor
  • Anxiety

The symptoms of a pheochromocytoma may look like other health problems. Always see your health care provider for a diagnosis.

How is pheochromocytoma diagnosed?

In addition to a complete health history and physical exam, you may need:

  • Blood and urine tests. These tests measure hormone levels.
  • CT scan. This test uses X-rays and computer technology to take detailed images of your body.
  • MRI. This test uses large magnets, radio waves, and a computer to make images of organs and structures within your body.
  • Radioisotope scan. This test puts radioactive substances into your body to take an image of the tumor. The substance is absorbed into tissues that make too much of the hormone epinephrine. During the scan this area lights up. This whole-body scan can show if the disease is spreading or if you have disease in other parts of your body.

How is a pheochromocytoma treated?

Your health care provider will figure out the best treatment for you based on:

  • How old you are
  • Your overall health and past health
  • How sick you are
  • How well you can handle specific medicines, procedures, or therapies
  • How long the condition is expected to last
  • Your opinion or preference

Treatment may include: 

  • Surgery. The surgeon may remove 1 or both adrenal glands.
  • Medicine. If you are too sick for surgery, you may take medicine. But this is rarely done. The tumor is mainly treated with surgery.

What are the complications of a pheochromocytoma?

Most of these tumors are benign. This means they are not cancer. Many will not come back after they are removed. If the tumor comes back or spreads to some other place in the body, it may be cancer. It is hard to tell a benign tumor from a cancerous one simply by looking at it.

Living with pheochromocytoma

You should follow your health care provider’s directions. See him or her as often as needed to make sure the tumor hasn’t returned. You may also still have high blood pressure after the tumor is removed.

When should I call my health care provider?

Tell your health care provider if your symptoms come back or get worse. Also let him or her know if you have any new symptoms.

Key points about pheochromocytomas

  • A pheochromocytoma is a tumor in the adrenal gland. It causes the gland to make too much of the hormones epinephrine and norepinephrine.
  • This tumor usually occurs when you are in your 30s, 40s, or 50s. It happens to both men and women.
  • Family history is believed to be the major cause of pheochromocytomas.
  • The most common sign of this tumor is high blood pressure.
  • Most pheochromocytomas are not cancer. They will not come back after they are removed.

Next steps

Tips to help you get the most from a visit to your health care provider:
  • Before your visit, write down questions you want answered.
  • Bring someone with you to help you ask questions and remember what your provider tells you.
  • At the visit, write down the names of new medicines, treatments, or tests, and any new instructions your provider gives you.
  • If you have a follow-up appointment, write down the date, time, and purpose for that visit.
  • Know how you can contact your provider if you have questions.
Pheochromocytoma: An Adrenal Gland Tumor - WellSpan Health

Online Medical Reviewer: Hanrahan, John, MD
Online Medical Reviewer: newMentor board-certified, academically affiliated clinician
Last Review Date: 2014-02-23T00:00:00
Last Modified Date: 2015-11-12T00:00:00
Published Date: 2015-11-12T00:00:00
Last Review Date: 2007-03-30T00:00:00
© 2016 WellSpan Health. All Rights Reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

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