WellSpan Home

Monoclonal Gammopathy of Unknown Significance (MGUS)

Monoclonal gammopathy of unknown significance (MGUS) is a blood condition in which a person's body makes too many of the same type of protein that fight infections.

The blood has a large number of different proteins called the plasma proteins. One type of protein is called gamma globulin. Normally, many different types of gamma globulin are made to fight different infections. When most of the protein being made is all from cells of the original (clone) gamma globulin protein, this is called monoclonal gammopathy. Most people with MGUS have a low monoclonal protein level.

Generally, MGUS does not cause symptoms or major health problems. It is often found by chance when lab tests are done for other reasons, such as to measure the level of protein in the blood. Monoclonal antibodies can attach to nerves and cause numbness, tingling, and weakness. Most people with MGUS are fine for many years and do not need any treatment. In some cases MGUS can change and progress to a cancer, such as multiple myeloma, macroglobulinemia, or B-cell lymphoma.

People who have MGUS may need a physical exam, blood tests, and urine tests two times a year to see if it is progressing to cancer so that treatment can be started early.


Are you sure you would like to cancel?

All information will be lost.

Yes No ×

About the provider search

This search will provide you with WellSpan Medical Group and Northern Lancaster County (Ephrata) Medical Group primary care physicians and specialists. If we don’t have a WellSpan Medical Group physician to meet your criteria, the search will expand to include community physicians who partner with WellSpan Medical Group physicians through the WellSpan Provider Network or provide care to patients on the Medical Staffs of WellSpan’s Hospitals.

×

Schedule Your Next Appointment Online with MyWellSpan

Use your MyWellSpan patient portal any time to view available appointments, and pick the date and time that best suits your schedule.

Go to MyWellSpan

New to this practice?

If you don't have a WellSpan primary care provider and would like to schedule a new patient appointment with a provider who is accepting patients, just log into your MyWellSpan account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to see the offices that are accepting new patients in relation to your zip code. If you are not enrolled in MyWellSpan, go to https://my.wellspan.org, call 1-866-638-1842 or speak with a member of the staff at a participating facility to sign up. New patient scheduling not available at all practices/programs.

Already a patient at this practice?

If you already have a relationship with a WellSpan practice, simply log into your account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to schedule an appointment with any provider or practice that already counts you as a patient. Online scheduling varies by practice/program.

×