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A cortisol test measures the level of the hormone cortisol in a 24-hour sample of urine. The cortisol level may show problems with the adrenal glands or the pituitary gland. Cortisol is made by the adrenal glands. Cortisol levels get higher when the pituitary gland releases adrenocorticotropic hormone (ACTH).
Cortisol has many functions. It helps the body use sugar (glucose) and fat for energy (metabolism). It helps the body manage stress. Cortisol levels can be affected by many things, such as physical or emotional stress, strenuous activity, infection, or injury.
Normally, cortisol levels rise during the early morning hours and are highest about 7 a.m. They drop very low in the evening and during the early phase of sleep. But if you sleep during the day and are up at night, this pattern may be reversed. If you do not have this daily change in cortisol levels, you may have overactive adrenal glands.
Cortisol levels vary widely throughout the day, so you collect urine over 24 hours for this test.
A cortisol test is done to find problems of the pituitary gland or adrenal glands, such as making too much hormone.
You may be asked to avoid strenuous physical activity the day before the test.
Be sure to drink enough fluids during the 24-hour urine test. This prevents dehydration.
This test is usually done at home. You must collect all the urine you produce in a 24-hour period.
This test usually doesn't cause any pain or discomfort.
There are no known risks from having this test.
Each lab has a different range for what's normal. Your lab report should show the range that your lab uses for each test. The normal range is just a guide. Your doctor will also look at your results based on your age, health, and other factors. A value that isn't in the normal range may still be normal for you.
High values of cortisol may be caused by:
Current as of:
April 13, 2022
Author: Healthwise StaffMedical Review: E. Gregory Thompson MD - Internal MedicineKathleen Romito MD - Family MedicineAlan C. Dalkin MD - Endocrinology
Current as of: April 13, 2022
E. Gregory Thompson MD - Internal Medicine & Kathleen Romito MD - Family Medicine & Alan C. Dalkin MD - Endocrinology
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