Closures & Hours Changes
Top of the page
A cold agglutinins blood test is done to check for conditions that cause the body to make certain types of antibodies called cold agglutinins. Cold agglutinins are normally made by the immune system in response to infection. They cause red blood cells to clump together (agglutinate) at low temperatures.
Healthy people generally have low levels of cold agglutinins in their blood. But lymphoma or some infections, such as mycoplasma pneumonia, can cause the level of cold agglutinins to rise.
Higher-than-normal levels of cold agglutinins generally do not cause serious problems. Sometimes, high levels of cold agglutinins can cause blood to clump in blood vessels under the skin when the skin is exposed to the cold. This causes pale or bluish skin and numbness in the hands and feet. The symptoms go away when the skin warms up.
Sometimes high levels of cold agglutinins can destroy red blood cells throughout the body. This condition is called autoimmune hemolytic anemia.
A cold agglutinins test may be done to see whether high cold agglutinin levels are causing autoimmune hemolytic anemia.
In general, there's nothing you have to do before this test, unless your doctor tells you to.
A health professional uses a needle to take a blood sample, usually from the arm.
When a blood sample is taken, you may feel nothing at all from the needle. Or you might feel a quick sting or pinch.
There is very little chance of having a problem from this test. When a blood sample is taken, a small bruise may form at the site.
Each lab has a different range for what's normal. Your lab report should show the range that your lab uses for each test. The normal range is just a guide. Your doctor will also look at your results based on your age, health, and other factors. A value that isn't in the normal range may still be normal for you.
Current as of:
May 14, 2023
Author: Healthwise StaffClinical Review Board: All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.
Current as of: May 14, 2023
Clinical Review Board:
All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.
To learn more about Healthwise, visit Healthwise.org.
© 1995-2023 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Pay a Bill
Closures & Hours Changes
For Medical Professionals
Graduate Medical Education
Nursing at WellSpan
Clinical Research Programs
Who We Are
Make a Donation
Connect With Us
Non-Discrimination Statement/Language Access
Aviso Contra la Discriminación/Acceso a diferentes lenguajes
© WellSpan Health | Disclaimer & Policies