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Avapritinib Oral Tablet (AVAPRITINIB - ORAL)

This medicine is used for the following purposes:

  • blood cell disorder
  • cancer

Brand Name(s): Ayvakit

Generic Name: Avapritinib

Instructions

Take on empty stomach - 1 hour before or 2 hours after eating.

Swallow with a full glass (8 oz) of water unless your doctor gives you different instructions.

This medicine will work best if you take it at about the same time every day.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

Please ask your doctor, nurse, or pharmacist how to discard unused medicines safely.

Avoid grapefruit and grapefruit juice while on this medicine.

If you vomit after taking a dose, do not take an extra dose. Take your next dose at the usual time.

This medicine can make you sensitive to the sun. Use sunscreen or protective clothing when in sun.

If you forget to take a dose on time, take it as soon as you remember. If it is almost time for the next dose, do not take the missed dose. Return to your normal schedule. Do not take 2 doses at one time.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Do not use the medication any more than instructed.

This medicine may cause dizziness or fainting, especially after exercising or in hot weather. Be very careful when standing or sitting up quickly.

If possible, avoid using with marijuana or other medicines that can cause dizziness or drowsiness. These include allergy/cold products, muscle relaxers, sleep aids, and pain relievers.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

Please check with your doctor before drinking alcohol while on this medicine.

This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Do not breastfeed while on this medicine. You may safely start breastfeeding 2 weeks after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women of childbearing age should have a negative pregnancy test before starting this medicine.

Women must use reliable forms of birth control while taking this medicine and for 6 weeks after stopping to prevent pregnancy.

Men with a female partner who is of childbearing age must use reliable birth control during sexual activity while taking this medicine and for 6 weeks after stopping to prevent pregnancy.

Women who are pregnant or in their childbearing years should not touch or handle this medicine. This medicine can be absorbed through the woman's skin and harm the unborn baby.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • decreased appetite
  • diarrhea
  • dizziness or drowsiness
  • lack of energy and tiredness
  • hair loss
  • muscle weakness
  • nausea and vomiting
  • stomach upset or abdominal pain
  • changes in taste or unpleasant taste

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • agitated feeling or trouble sleeping
  • changes in memory, mood, or thinking
  • confusion
  • depression or feeling sad
  • fever or chills
  • hallucinations (unusual thoughts, seeing or hearing things that are not real)
  • severe or persistent headache
  • irritability
  • red, burning, or itchy skin
  • restlessness
  • difficulty speaking
  • symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
  • unusual or unexplained tiredness or weakness
  • blurring or changes of vision
  • severe or persistent vomiting

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

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