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sirolimus protein-bound

Pronunciation: sir OH li mus PROE teen bownd

Brand: Fyarro

What is the most important information I should know about sirolimus protein-bound?

Both men and women using this medicine should use effective birth control to prevent pregnancy. Sirolimus protein-bound can harm an unborn baby if the mother or father is using this medicine.

What is sirolimus protein-bound?

Sirolimus protein-bound is used to treat adults with a certain type of perivascular epithelioid cell tumor (PEComa).

Sirolimus protein-bound may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving sirolimus protein-bound?

You should not use sirolimus protein-bound if you are allergic to it, other rapamycin derivatives, or albumin.

Tell your doctor if you have ever had:

  • liver disease;
  • diabetes;
  • breathing problems; or
  • bleeding problems.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Sirolimus protein-bound can harm an unborn baby if the mother or father is using this medicine.

Keep using birth control for at least 12 weeks after your last dose. Tell your doctor right away if a pregnancy occurs.

You will need to have a negative pregnancy test before starting this treatment.

Sirolimus protein-bound may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

How is sirolimus protein-bound given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Sirolimus protein-bound is injected into a vein by a healthcare professional over a 30-minute period on days 1 and 8 of each 21-day treatment cycle.

Your blood sugar will need to be checked on a regular basis, and you may need other medical tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving sirolimus protein-bound?

Avoid receiving a "live" vaccine. The vaccine may not work as well while you are using sirolimus protein-bound. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

Grapefruit may interact with sirolimus protein-bound and cause side effects. Avoid consuming grapefruit products.

What are the possible side effects of sirolimus protein-bound?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • sudden chest pain, wheezing, dry cough, feeling short of breath;
  • nosebleeds, bleeding gums, abnormal vaginal bleeding, any bleeding that will not stop;
  • low blood potassium --leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
  • signs of infection --fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding; or
  • low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • fever, chills, sore throat, body aches, loss of appetite, bruising or bleeding;
  • tiredness;
  • cough;
  • altered sense of taste;
  • rash;
  • nausea, diarrhea, vomiting;
  • swelling;
  • muscle, bone, or joint pain; or
  • loss of weight and appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sirolimus protein-bound?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect sirolimus protein-bound, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about sirolimus protein-bound.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 1.01. Revision date: 9/21/2022.

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