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Pronunciation: AM ee VAN ti mab

Brand: Rybrevant

What is the most important information I should know about amivantamab?

Amivantamab can cause skin reactions. Avoid sunlight while you are receiving this medicine and for 2 months after your last dose.

What is amivantamab?

Amivantamab is used to treat non-small cell lung cancer that has an abnormal "EGFR" gene and has spread to other parts of the body (metastatic) or cannot be removed with surgery. Your doctor will make sure you have the correct tumor type to be treated with this medicine.

Amivantamab is given after other treatments did not work or stopped working.

Amivantamab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking amivantamab?

Tell your doctor if you have ever had lung problems other than cancer.

May harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use birth control while using amivantamab and for at least 3 months after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

How should I take amivantamab?

Amivantamab is injected into a vein by a healthcare provider, usually every 2 to 4 weeks.

This medicine is injected slowly over several hours.

You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.

You may need frequent vision exams.

May cause rash, itching, and dry skin. Use only alcohol-free cream or lotion to treat dry skin.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your amivantamab injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while taking amivantamab?

Amivantamab can cause skin reactions. Avoid sunlight and tanning beds during treatment and for 2 months after your last dose. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

If you have problems with your eyes, avoid wearing contact lenses until your symptoms can be checked by an eye doctor.

What are the possible side effects of amivantamab?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Some side effects may occur during the injection. Tell your care provider if you feel nauseated, light-headed, short of breath, chilled or feverish, or if you have chest discomfort.

Call your doctor at once if you have:

  • eye pain or redness, itching, watery eyes, sensitivity to light;
  • vision changes;
  • dark floating spots in your field of vision (floaters);
  • skin changes such as acne, itching, or dryness; or
  • lung problems (may be similar to symptoms of your cancer) --new or worsening cough, fever, or shortness of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • a reaction during the injection;
  • cough, shortness of breath;
  • feeling very tired;
  • rash;
  • infection of the a skin around your nails;
  • swelling anywhere in your body;
  • nausea, vomiting, constipation;
  • mouth sores;
  • joint or muscle pain; or
  • abnormal blood tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amivantamab?

Other drugs may affect amivantamab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your pharmacist can provide more information about amivantamab.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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