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risankizumab

Pronunciation: RIS an KIZ ue mab

Brand: Skyrizi

What is the most important information I should know about risankizumab?

Risankizumab affects your immune system. You may get infections more easily. Call your doctor if you have symptoms such as fever, chills, cough, trouble breathing, diarrhea, burning when you urinate, weight loss, or skin sores on your body (different from psoriasis).

What is risankizumab?

Risankizumab is used to treat moderate to severe plaque psoriasis in adults.

Risankizumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using risankizumab?

Before you start treatment with risankizumab, your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.

Tell your doctor if you currently have signs of infection such as fever, chills, muscle pain, cough, trouble breathing, skin sores, stomach pain, diarrhea, weight loss, or painful urination.

Make sure you are current on all vaccines before you begin treatment with risankizumab.

Tell your doctor if you are pregnant or breastfeeding.

Risankizumab is not approved for use by anyone younger than 18 years old.

How should I use risankizumab?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Risankizumab is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. You may need to use 2 injections to get your total dose. Ask your doctor or pharmacist if you don't understand all instructions.

Risankizumab should be clear or light-yellow. Do not use if the medicine looks cloudy, has changed colors, or has flakes or large particles in it. Call your pharmacist for new medicine.

Your care provider will show you where on your body to inject risankizumab. Do not inject into skin with active psoriasis, or skin that is red, bruised, or tender. Do not inject within 2 inches of your navel (belly button).

Risankizumab affects your immune system. You may get infections more easily. Your doctor will need to examine you on a regular basis.

Store this medicine in the original container in a refrigerator. Protect from light and do not shake or freeze. Take the medicine out of the refrigerator and allow it to reach room temperature for 15 to 30 minutes before injecting your dose. Do not heat the medicine in a microwave or with hot water.

Each prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using risankizumab?

Do not receive a "live" vaccine while using risankizumab. The vaccine may not work as well and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What are the possible side effects of risankizumab?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You may get infections more easily. Call your doctor right away if you have signs of infection such as:

  • fever, chills, sweating, body aches;
  • shortness of breath, cough, bloody mucus;
  • mouth sores, red or swollen gums;
  • stomach pain, diarrhea;
  • increased urination, burning when you urinate;
  • pale skin, easy bruising, unusual bleeding;
  • a fungal skin infection --skin sores different from psoriasis, rash or redness, blisters, itching, burning, cracking or peeling, changes in skin color; or
  • signs of tuberculosis: fever, cough, night sweats, loss of appetite, weight loss, and feeling very tired.

If you develop an infection, you may need to postpone your next injection until the infection clears up.

Common side effects may include:

  • headache;
  • tiredness;
  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • fungal skin infections; or
  • pain, redness, itching, bruising, swelling, warmth, bleeding, burning, or other skin irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect risankizumab?

Other drugs may affect risankizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about risankizumab.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 1.02. Revision date: 7/15/2019.

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