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ertugliflozin and sitagliptin

Pronunciation: test

Brand: Steglujan

What is the most important information I should know about ertugliflozin and sitagliptin?

You should not use this medicine if you have severe kidney disease, if you are on dialysis, or if you have diabetic ketoacidosis. Ertugliflozin and sitagliptin is not for treating type 1 diabetes.

This medicine can make you dehydrated, which could cause you to feel weak or dizzy (especially when you stand up).

Ertugliflozin can also cause infections in the bladder or genitals (penis or vagina). Call your doctor if you have genital pain or itching, genital odor or discharge, increased urination, pain or burning when you urinate, or blood in your urine.

Stop taking ertugliflozin and sitagliptin and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.

What is ertugliflozin and sitagliptin?

Ertugliflozin and sitagliptin helps control blood sugar levels. Ertugliflozin works by helping the kidneys get rid of glucose from your bloodstream. Sitagliptin works by regulating the levels of insulin your body produces after eating.

Ertugliflozin and sitagliptin is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

Ertugliflozin and sitagliptin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ertugliflozin and sitagliptin?

You should not use this medicine if you are allergic to ertugliflozin o sitagliptin, or if you have:

  • severe kidney disease (or if you are on dialysis); or
  • diabetic ketoacidosis (call your doctor for treatment).

To make sure ertugliflozin and sitagliptin is safe for you, tell your doctor if you have ever had:

  • liver or kidney disease;
  • a bladder infection or urination problems;
  • heart problems, high blood pressure;
  • low blood pressure;
  • blood circulation problems, especially in your legs;
  • nerve damage in your legs;
  • a diabetic foot ulcer or amputation;
  • gallstones;
  • problems with your pancreas, including surgery;
  • high triglycerides (a type of fat in blood);
  • a history of alcoholism; or
  • if you are on a low salt diet.

Follow your doctor's instructions about using ertugliflozin and sitagliptin if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy.

Ertugliflozin may harm an unborn baby if you take the medicine during your second or third trimester. Tell your doctor if you become pregnant while using ertugliflozin and sitagliptin.

It is not known whether ertugliflozin and sitagliptin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Ertugliflozin and sitagliptin is not approved for use by anyone younger than 18 years old.

How should I take ertugliflozin and sitagliptin?

This medicine is usually taken once per day in the morning. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take ertugliflozin and sitagliptin with or without food.

Call your doctor if you are sick with vomiting or diarrhea, if you consume less food or fluid than usual, or if you are sweating more than usual.

Your blood sugar will need to be checked often, and you may also need to test the level of ketones your urine. Ertugliflozin can cause life-threatening ketoacidosis (too much acid in the blood). Even if your blood sugar is normal, contact your doctor if a urine test shows that you have ketones in the urine.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

This medicine can cause unusual results with certain lab tests. Tell any doctor who treats you that you are using ertugliflozin and sitagliptin.

This medicine is only part of a treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat. Keep unused tablets in the foil blister pack in its original container.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking ertugliflozin and sitagliptin?

Avoid drinking alcohol. It may increase your risk of pancreatitis while you are taking ertugliflozin and sitagliptin.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of ertugliflozin and sitagliptin?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Stop taking this medicine and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.

Call your doctor at once if you have:

  • severe autoimmune reaction --itching, blisters, breakdown of the outer layer of skin;
  • new pain, tenderness, sores, ulcers, or infections in your legs or feet;
  • severe or ongoing pain in your joints;
  • little or no urination;
  • ketoacidosis (too much acid in the blood) --nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing;
  • dehydration symptoms --dizziness, weakness, feeling light-headed (like you might pass out);
  • signs of a bladder infection --pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back; or
  • signs of a genital infection (penis or vagina) --pain, burning, itching, rash, redness, odor, or discharge; or
  • symptoms of heart failure --shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain.

Some side effects may be more likely to occur in older adults.

Common side effects may include:

  • genital infections;
  • urinating more than usual;
  • upset stomach, diarrhea;
  • headache; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ertugliflozin and sitagliptin?

When you start or stop taking ertugliflozin and sitagliptin, your doctor may need to adjust the doses of any other diabetes medicines you use on a regular basis.

Other drugs may interact with ertugliflozin and sitagliptin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about ertugliflozin and sitagliptin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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