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dolutegravir and rilpivirine

Pronunciation: test

Brand: Juluca

What is the most important information I should know about dolutegravir and rilpivirine?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is dolutegravir and rilpivirine?

Dolutegravir and rilpivirine are antiviral medicines that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Dolutegravir and rilpivirine is used to treat HIV, the virus that can cause the acquired immunodeficiency syndrome (AIDS). This medicine is not a cure for HIV or AIDS.

Dolutegravir and rilpivirine is for use only in people who have been successfully treated with other antiviral medications for at least 6 months.

Dolutegravir and rilpivirine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking dolutegravir and rilpivirine?

You should not use this medicine if you are allergic to dolutegravir or rilpivirine.

Some medicines can cause unwanted or dangerous effects when used with dolutegravir and rilpivirine. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • dofetilide (can cause serious medical problems or death when taken with dolutegravir and rilpivirine);
  • St John's wort;
  • more than one dose of dexamethasone;
  • carbamazepine, oxcarbazepine, phenobarbital, phenytoin;
  • rifabutin, rifampin, rifapentine; or
  • esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole.

Tell your doctor if you have ever had:

  • liver disease, especially hepatitis B or C (this medicine can cause hepatitis to come back or get worse).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of dolutegravir and rilpivirine on the baby.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take dolutegravir and rilpivirine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Always take this medicine with food, not with a meal replacement drink.

You will need frequent blood tests.

Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Get your prescription refilled before you run out of medicine completely.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with any packet or canister of moisture-absorbing preservative.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking dolutegravir and rilpivirine?

This medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of dolutegravir and rilpivirine?

Stop taking this medicine and get emergency medical help if you have signs of an allergic reaction: fever, general ill feeling, trouble breathing, extreme tiredness; mouth sores, redness or swelling in your eyes; blistering or peeling skin; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • thoughts about suicide or hurting yourself;
  • anxiety, sadness, feeling hopeless; or
  • liver problems --nausea, vomiting, loss of appetite, right-sided upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • headache; or
  • diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dolutegravir and rilpivirine?

Some medicines can make dolutegravir and rilpivirine less effective when taken at the same time. If you take any of the following medicines, take your dolutegravir and rilpivirine dose at least 4 hours before or 6 hours after you take the other medicine.

  • antacids or laxatives that contain calcium, magnesium, or aluminum (such as Maalox, Milk of Magnesia, Mylanta, Rolaids, Tums, and others), or the ulcer medicine sucralfate (Carafate);
  • buffered medicine; or
  • vitamin or mineral supplements that contain calcium or iron (but if you take dolutegravir and rilpivirine with food, you can take these supplements at the same time).

Many drugs can interact with dolutegravir and rilpivirine, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about dolutegravir and rilpivirine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 1.01. Revision date: 2/12/2018.

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