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durvalumab

Pronunciation: dur VAL ue mab

Brand: Imfinzi

What is the most important information I should know about durvalumab?

Durvalumab may cause serious or life-threatening side effects on your lungs, liver, pancreas, kidneys, intestines, thyroid, or adrenal glands.

Call your doctor at once if you have new or unusual symptoms, such as: tiredness, mood changes, headaches, vision problems, muscle weakness, stomach problems, weight changes, skin rash, hair loss, bleeding or bruising, yellowing of your skin or eyes, increased or decreased urination, dark urine, bloody or tarry stools, worsening cough, chest pain, or trouble breathing.

What is durvalumab?

Durvalumab is used to treat non-small cell lung cancer, and cancer of the bladder or urinary tract.

Durvalumab is sometimes given when the cancer has spread to other parts of the body or cannot be removed with surgery, or when other treatments did not work or have stopped working.

Durvalumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving durvalumab?

Tell your doctor if you have an active infection, or if you have ever had:

  • an organ transplant;
  • lung disease or breathing problems;
  • liver disease; or
  • an autoimmune disorder such as lupus, ulcerative colitis, or Crohn's disease.

Durvalumab may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose. Tell your doctor if you become pregnant.

Do not breast-feed while using durvalumab, and for at least 3 months after your last dose.

How is durvalumab given?

Durvalumab is given as an infusion into a vein, usually once every 2 weeks. A healthcare provider will give you this injection.

This medicine must be given slowly and the infusion can take about 1 hour to complete.

You may need frequent medical tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your durvalumab injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving durvalumab?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of durvalumab?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel light-headed or itchy, or if you have a fever, chills, neck or back pain, trouble breathing, or flushing (warmth, redness, or tingly feeling).

Durvalumab causes your immune system to attack tumor cells, but it could also attack healthy organs and tissues in your body. This could lead to serious or life-threatening side effects on your lungs, liver, pancreas, kidneys, intestines, thyroid, or adrenal glands.

Call your doctor at once if you have:

  • chest pain, new or worsening cough, feeling short of breath;
  • severe stomach pain, diarrhea, bloody or tarry stools;
  • new or worsening skin rash, itching, or blistering;
  • fever, flu-like symptoms;
  • pain or burning when you urinate;
  • problems in other organs --mood or behavior changes, neck stiffness, confusion, eye pain or redness, vision problems;
  • liver problems --loss of appetite, upper stomach pain, drowsiness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes);
  • kidney problems --little or no urination, red or pink urine, swelling in your feet or ankles; or
  • signs of a hormonal disorder --unusual headaches, feeling light-headed or very tired, hoarse or deepened voice, increased hunger or thirst, increased urination, constipation, vomiting, hair loss, feeling cold, weight gain, or weight loss.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, constipation, loss of appetite;
  • tiredness, bone pain, muscle pain;
  • cough, feeling short of breath;
  • painful urination;
  • rash; or
  • swelling in your arms and legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect durvalumab?

Other drugs may affect durvalumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about durvalumab.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 2.01. Revision date: 2/14/2019.

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