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olodaterol and tiotropium

Pronunciation: OH loe DAT er ol and TYE oh TROE pee um

Brand: Stiolto Respimat 28 ACT, Stiolto Respimat 60 ACT

What is the most important information I should know about olodaterol and tiotropium?

Olodaterol and tiotropium is for use only in people with chronic obstructive pulmonary disease (COPD) and should not be used to treat asthma.

Olodaterol and tiotropium may increase the risk of death or hospitalization in people with asthma, but the risk in people with COPD is not known.

Call your doctor at once if you have new or worsening COPD symptoms.

What is olodaterol and tiotropium?

Olodaterol and tiotropium is a combination medicine used to prevent airflow obstruction or bronchospasm in people with COPD (chronic obstructive pulmonary disease). Olodaterol and tiotropium will not treat a bronchospasm attack that has already begun.

Olodaterol and tiotropium is for use only in people with COPD and should not be used to treat asthma.

Olodaterol and tiotropium may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using olodaterol and tiotropium?

You should not use this medicine if you are allergic to olodaterol, tiotropium, or ipratropium (Atrovent, Combivent, DuoNeb).

Olodaterol and tiotropium may increase the risk of death or hospitalization in people with asthma, but the risk in people with COPD is not known. Talk with your doctor about your own risk.

Tell your doctor if you have ever had:

  • heart disease, high blood pressure;
  • seizures;
  • a thyroid disorder;
  • diabetes;
  • glaucoma;
  • kidney disease; or
  • an enlarged prostate or urination problems.

Tell your doctor if you are pregnant or breast-feeding.

Olodaterol and tiotropium is not approved for use by anyone younger than 18 years old.

How should I use olodaterol and tiotropium?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

The usual dose of this medicine is 2 inhalations once per day. Use the medicine at the same time each day, and not more than once in a 24-hour period. Using too much of this medicine can cause life-threatening side effects.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use only the inhaler device provided with your medicine or you may not get the correct dose. Use the new inhaler each time you get your prescription refilled.

Olodaterol and tiotropium is not a rescue medicine for bronchospasm attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well.

Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

Store at room temperature. Do not allow the medicine to freeze.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Do not use more than two inhalations every 24 hours.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using olodaterol and tiotropium?

Avoid getting this medicine in your eyes.

Do not use a second inhaled bronchodilator unless your doctor tells you to. This includes albuterol (Combivent, DuoNeb), arformoterol (Brovana), formoterol (Perforomist, Symbicort, Bevespi, Dulera), indacaterol (Arcapta), olodaterol (Striverdi), salmeterol (Serevent), or vilanterol (Breo Ellipta).

This medicine may cause dizziness and blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

What are the possible side effects of olodaterol and tiotropium?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • wheezing, choking, or other breathing problems after using this medicine;
  • new or worsening COPD symptoms, sudden shortness of breath;
  • painful or difficult urination;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • severe headache, pounding in your neck or ears;
  • chest pain, fast or pounding heartbeats, fluttering in your chest;
  • high blood sugar --increased thirst, increased urination, hunger, dry mouth, fruity breath odor; or
  • low potassium --leg cramps, constipation, irregular heartbeats, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects may include:

  • runny nose;
  • cough; or
  • back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect olodaterol and tiotropium?

Tell your doctor about all your other medicines, especially:

  • atropine;
  • medicine to treat depression, anxiety, mood disorders, or mental illness;
  • cold or allergy medicine (Benadryl and others);
  • medicine to treat Parkinson's disease;
  • medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;
  • medicine to treat overactive bladder; or
  • other bronchodilator asthma medication.

This list is not complete. Other drugs may affect olodaterol and tiotropium, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about olodaterol and tiotropium.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 3.01. Revision date: 11/9/2018.

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