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olaparib

Pronunciation: oh LAP a rib

Brand: Lynparza

What is the most important information I should know about olaparib?

Olaparib affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, weakness, tiredness, trouble breathing, easy bruising or bleeding, blood in your urine or stools, or weight loss.

You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.

Some people who take olaparib with a gonadotropin-releasing hormone (GnRH) medicine may develop a blood clot in the leg or in the lung. Call your doctor if you have pain or swelling in your arm or leg, shortness of breath, chest pain, rapid breathing, or fast heartbeats.

Olaparib may also cause serious lung problems. Call your doctor if you have chest pain, wheezing, trouble breathing, or a new or worsening cough.

What is olaparib?

Olaparib is used to treat cancers of the breast, ovary, fallopian tube, pancreas, prostate, or peritoneum (the membrane that lines the inside of your abdomen and covers some of your internal organs).

Olaparib is sometimes used when the cancer has spread to other parts of the body, or when cancer has come back after treatment with other medications.

Olaparib is sometimes used only if your cancer has a specific genetic marker (an abnormal "BRCA" or "HRR" gene). Your doctor will test you for this gene.

Olaparib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking olaparib?

You should not use olaparib if you are allergic to it.

Tell your doctor if you have ever had:

  • lung disease, breathing problems; or
  • kidney disease.

Olaparib can harm an unborn baby or cause a miscarriage if the mother or the father is using this medicine.

  • If you are a woman, do not use this medicine if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Also do not to donate sperm during the 3 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using olaparib.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

How should I take olaparib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take your doses at regular intervals, about 12 hours apart. You may take olaparib with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

Olaparib affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

You may also need chest x-rays to be sure this medicine is not causing harmful effects on your lungs. Your cancer treatments may be delayed based on the results.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Do not take more than 4 olaparib tablets in one day.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking olaparib?

Grapefruit and Seville oranges may interact with olaparib and lead to unwanted side effects. Avoid the use of grapefruit products and orange marmalades.

What are the possible side effects of olaparib?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

  • fever, chills, weakness, feeling light-headed or very tired;
  • mouth sores, skin sores;
  • easy bruising, unusual bleeding;
  • pain or burning when you urinate, blood in your urine or stools;
  • pale skin, cold hands and feet
  • weight loss; or
  • cough, wheezing, shortness of breath.

Your cancer treatments may be delayed if you have certain side effects.

Some people who take olaparib with a gonadotropin-releasing hormone (GnRH) medicine may develop a blood clot in the leg or in the lung. Call your doctor if you have pain or swelling in your arm or leg, shortness of breath, chest pain, rapid breathing, or fast heartbeats.

Common side effects may include:

  • low blood cell counts;
  • pain and burning when you urinate, painful urination;
  • nausea, vomiting, upper stomach pain, diarrhea;
  • heartburn, indigestion, loss of appetite;
  • dizziness, feeling weak or tired;
  • headache;
  • cough, shortness of breath; or
  • altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect olaparib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect olaparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about olaparib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2020 Cerner Multum, Inc. Version: 6.01. Revision date: 6/4/2020.

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