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canagliflozin

Pronunciation: KAN a gli FLOE zin

Brand: Invokana

Invokana

slide 1 of 2, Invokana,

100 mg, capsule, yellow, imprinted with CFZ, 100

 Image of Invokana
slide 1 of 2
    

Invokana

slide 2 of 2, Invokana,

300 mg, capsule, white, imprinted with CFZ, 300

 Image of Invokana
slide 2 of 2
    

What is the most important information I should know about canagliflozin?

You should not use canagliflozin if you have severe kidney disease or if you are on dialysis.

Canagliflozin may increase your risk of lower leg amputation, especially if you have had a prior amputation, a foot ulcer, heart disease, circulation problems, or nerve damage.

Canagliflozin can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

What is canagliflozin?

Canagliflozin is an oral diabetes medicine that helps control blood sugar levels. Canagliflozin works by helping the kidneys get rid of glucose from your bloodstream.

Canagliflozin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Canagliflozin is not for treating type 1 diabetes.

Canagliflozin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking canagliflozin?

You should not use canagliflozin if you are allergic to it, or if you have:

  • severe kidney disease (or if you are on dialysis).

Canagliflozin may increase your risk of lower leg amputation, especially if you have had a prior amputation, a foot ulcer, heart disease, circulation problems, or nerve damage.

Tell your doctor if you have ever had:

  • heart problems;
  • a diabetic foot ulcer or amputation;
  • circulation problems or nerve problems in your legs or feet;
  • kidney disease;
  • liver disease;
  • bladder infections or other urination problems;
  • a pancreas disorder;
  • diabetic ketoacidosis; or
  • if you are on a low salt diet.

Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.

You should not use canagliflozin during the second or third trimester of pregnancy.

You should not breast-feed while using this medicine.

Canagliflozin is not approved for use by anyone younger than 18 years old.

How should I take canagliflozin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Canagliflozin is usually taken once per day, before the first meal of the day.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Drink plenty of liquids while you are taking canagliflozin.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Canagliflozin is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using canagliflozin.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking canagliflozin?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

What are the possible side effects of canagliflozin?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have signs of a genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • little or no urination;
  • pain or burning when you urinate;
  • new pain, tenderness, sores, ulcers, or infections in your legs or feet;
  • high potassium --nausea, irregular heartbeats, weakness, loss of movement;
  • ketoacidosis (too much acid in the blood) --nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or
  • dehydration symptoms --dizziness, weakness, feeling light-headed (like you might pass out).

You may be more likely to have a broken bone while using canagliflozin. Talk with your doctor about how to avoid the risk of fractures.

Side effects may be more likely to occur in older adults.

Common side effects may include:

  • genital infections; or
  • urinating more than usual.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect canagliflozin?

Tell your doctor about all your other medicines, especially:

  • insulin or other oral diabetes medicines;
  • a diuretic or "water pill";
  • digoxin, digitalis;
  • rifampin;
  • ritonavir; or
  • seizure medication--phenobarbital, phenytoin.

This list is not complete. Other drugs may affect canagliflozin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about canagliflozin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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