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bupivacaine liposome

Pronunciation: bue PIV a kane LYE poe some

Brand: Exparel

What is the most important information I should know about bupivacaine liposome?

You may still feel numb or be unable to move the numbed area for up to 5 days after you are treated with bupivacaine liposome.

What is bupivacaine liposome?

Bupivacaine is an anesthetic (numbing medicine) that blocks nerve impulses in your body.

Bupivacaine liposome is used as a local (in only one area) anesthetic to numb an area of your body for a minor surgery such as bunion removal or hemorrhoid surgery.

Bupivacine liposome is also used as a nerve block after surgery on your shoulder or upper arm, to provide pain relief to the area.

Bupivacaine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving bupivacaine liposome?

You should not be treated with bupivacaine if you are allergic to it.

Tell your doctor if you have ever had:

  • an allergic reaction to any type of numbing medicine;
  • liver disease;
  • kidney disease;
  • heart disease;
  • a heart rhythm disorder; or
  • seizures.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

How is bupivacaine liposome given?

Bupivacaine is given as an injection placed into an area near your surgical incision. You will receive this injection in a hospital or surgical setting.

Bupivacaine liposome can have long-lasting or delayed effects. For at least 4 days (96 hours) after your surgery, tell any doctor or dentist who treats you that you recently received a bupivacaine liposome injection.

Call your doctor if you have joint pain or stiffness, or weakness in any part of your body that occurs after your surgery, even months later.

What happens if I miss a dose?

Since bupivacaine liposome is used as a single dose, it does not have a daily dosing schedule.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving bupivacaine liposome?

For at least 4 days (96 hours) after surgery, avoid using any pain or numbing medicines that contain lidocaine. This includes skin patches, sprays, creams, ointments, or gels applied to the skin. Follow your doctor's instructions.

What are the possible side effects of bupivacaine liposome?

Get emergency medical help if you have signs of an allergic reaction: hives, red rash, itching; sneezing, difficulty breathing; severe dizziness, vomiting; swelling of your face, lips, tongue, or throat.

You will be watched closely after receiving bupivacaine liposome, to make sure you do not have a reaction to the medicine. Tell your caregivers at once if you have any of these signs of a serious side effect:

  • ringing in your ears;
  • drowsiness, feeling restless or anxious;
  • feeling like you might pass out;
  • speech or vision problems, a metallic taste in your mouth;
  • numbness or tingling around your mouth;
  • fast or slow heart rate, feeling short of breath, feeling unusually hot or cold;
  • tremors, twitching, mood changes;
  • ongoing numbness, weakness, or loss of movement where the medicine was injected; or
  • joint pain or stiffness, or weakness in any part of your body for months after your surgery.

You may still feel numb or be unable to move the numbed area for up to 5 days after you are treated with bupivacaine liposome.

Common side effects include:

  • nausea, vomiting;
  • constipation; or
  • fever.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect bupivacaine liposome?

Other drugs may affect bupivacaine liposome, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about bupivacaine liposome.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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