WellSpan Home

ipilimumab

Pronunciation: IP i LIM ue mab

Brand: Yervoy

What is the most important information I should know about ipilimumab?

Serious and sometimes fatal reactions may occur during treatment with ipilimumab or months after stopping.

Call your doctor at once if you have symptoms such as:

  • diarrhea, increased bowel movements, black or bloody stools, stomach tenderness;
  • right-sided upper stomach pain, dark urine, jaundice (yellowing of the skin or eyes), easy bruising or bleeding;
  • unusual muscle weakness, numbness or tingling in your hands or feet;
  • unusual headaches, feeling cold or tired, weight gain, dizzy spells, mood changes, irritability, confusion;
  • mouth sores, skin rash with or without itching, blistering or peeling, skin sores with bleeding; or
  • eye pain or vision problems.

What is ipilimumab?

Ipilimumab is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Ipilimumab is used to treat melanoma (skin cancer) that cannot be treated with surgery, or that has spread to other parts of the body.

Ipilimumab is also used to prevent melanoma from coming back after surgery, including lymph node removal.

Ipilimumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving ipilimumab?

You should not receive ipilimumab if you are allergic to it.

To make sure ipilimumab is safe for you, tell your doctor if you have ever had:

  • liver damage (caused by disease or by using certain medicines);
  • an autoimmune disorder such as systemic lupus erythematosus (SLE) or sarcoidosis;
  • Crohn's disease or ulcerative colitis; or
  • if you have received an organ transplant.

Ipilimumab may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose. Tell your doctor if you become pregnant.

In animal studies, ipilimumab caused stillbirth, premature delivery, low birth weight, miscarriage in the third trimester, and infant death. However, very high doses are used in animal studies. It is not known whether these effects would occur in people using doses recommended for human use. Ask your doctor about your individual risk.

It is not known whether ipilimumab passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving ipilimumab and for at least 3 months after your last dose.

Ipilimumab is not approved for use by anyone younger than 12 years old.

How is ipilimumab given?

Ipilimumab is injected into a vein through an IV. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take at least 90 minutes to complete.

When used to treat melanoma, ipilimumab is usually given once every 3 weeks for up to 4 doses. When used to keep melanoma from coming back after surgery, additional doses are given once every 12 weeks for up to 3 years, or until your body no longer responds to the medicine.

Follow your doctor's dosing instructions very carefully.

You may be given other medications to treat or prevent certain side effects of ipilimumab.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your ipilimumab injection.

What happens if I overdose?

Since ipilimumab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving ipilimumab?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of ipilimumab?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious and sometimes fatal reactions may occur during treatment with ipilimumab or months after stopping. Call your doctor right away if you have symptoms such as:

  • diarrhea, increased bowel movements, black or bloody stools, stomach tenderness;
  • right-sided upper stomach pain, dark urine, jaundice (yellowing of the skin or eyes), easy bruising or bleeding;
  • unusual muscle weakness, numbness or tingling in your hands or feet;
  • unusual headaches, feeling cold or tired, weight gain, dizzy spells, mood changes, irritability, confusion;
  • mouth sores, skin rash with or without itching, blistering or peeling, skin sores with bleeding; or
  • eye pain, or vision problems.

Call your doctor at once if you have:

  • severe stomach pain, bloating, constipation, or vomiting;
  • loss of bowel control;
  • trouble with daily activities;
  • heavy sweating, hot and dry skin, feeling very thirsty or hot;
  • little or no urinating;
  • severe upper stomach pain spreading to your back, nausea and vomiting, fast heart rate;
  • fever, cough, trouble breathing; or
  • chest pain, feeling short of breath (even with mild exertion), swelling, rapid weight gain.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • headache, fever;
  • nausea, vomiting, diarrhea, loss of appetite;
  • tiredness, sleep problems (insomnia);
  • weight loss; or
  • mild skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ipilimumab?

Other drugs may interact with ipilimumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about ipilimumab.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 7.01. Revision date: 12/31/2017.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.

Are you sure you would like to cancel?

All information will be lost.

Yes No ×

About the provider search

This search will provide you with WellSpan Medical Group and Northern Lancaster County (Ephrata) Medical Group primary care physicians and specialists. If we don’t have a WellSpan Medical Group physician to meet your criteria, the search will expand to include community physicians who partner with WellSpan Medical Group physicians through the WellSpan Provider Network or provide care to patients on the Medical Staffs of WellSpan’s Hospitals.

×

Schedule Your Next Appointment Online with MyWellSpan

Use your MyWellSpan patient portal any time to view available appointments, and pick the date and time that best suits your schedule.

Go to MyWellSpan

New to this practice?

If you don't have a WellSpan primary care provider and would like to schedule a new patient appointment with a provider who is accepting patients, just log into your MyWellSpan account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to see the offices that are accepting new patients in relation to your zip code. If you are not enrolled in MyWellSpan, go to https://my.wellspan.org, call 1-866-638-1842 or speak with a member of the staff at a participating facility to sign up. New patient scheduling not available at all practices/programs.

Already a patient at this practice?

If you already have a relationship with a WellSpan practice, simply log into your account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to schedule an appointment with any provider or practice that already counts you as a patient. Online scheduling varies by practice/program.

×