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bismuth subcitrate potassium, metronidazole, and tetracycline

Pronunciation: BIZ muth sub SIT rate poe TASS ee um, MET roe NYE da zole, TET ra SYE kleen

Brand: Pylera

Pylera

slide 1 of 1, Pylera,

140 mg-125 mg-125 mg, capsule, white, imprinted with B M T, Aptalis

 Image of Pylera
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What is the most important information I should know about this medicine?

Do not drink alcohol or consume foods or medicines that contain propylene glycol while you are taking Pylera and for at least 3 days after you stop taking it.

Metronidazole has caused cancer in animal studies. It is not known whether this would occur in humans taking Pylera.

What is bismuth subcitrate potassium, metronidazole, and tetracycline (Pylera)?

Bismuth subcitrate potassium, metronidazole, and tetracycline (Pylera) is a combination medicine used to treat peptic ulcer (duodenal ulcer) with Helicobacter pylori infection. Pylera is usually given together with omeprazole (Prilosec).

Pylera may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking Pylera?

You should not use Pylera if you are allergic to bismuth subcitrate potassium, metronidazole, or tetracycline, or if:

  • you have severe kidney disease;
  • you drink alcohol daily;
  • you regularly consume foods or medicines that contain propylene glycol;
  • you took disulfiram (Antabuse) within the past 14 days; or
  • you also use methoxyflurane.

Tell your doctor if you have ever had:

  • kidney disease;
  • liver disease;
  • Cockayne syndrome (a rare genetic disorder);
  • a blood cell disorder; or
  • any type of infection.

Metronidazole has caused cancer in animal studies. It is not known whether this would occur in humans taking Pylera. Ask your doctor about your risk.

Do not use Pylera if you are pregnant. Tetracycline can cause permanent tooth discoloration and affect growth in the baby.

Pylera can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge.

You should not breastfeed within 2 days after using Pylera. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

Not approved for use by anyone younger than 18 years old.

How should I take Pylera?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take your medicine with a full glass (8 ounces) of water. Swallow the capsule whole. Do not take with milk.

Pylera is usually taken after meals and at bedtime. If you also take omeprazole (Prilosec), take it after your morning and evening meals.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Pylera will not treat a viral infection (flu or a common cold).

Bismuth can affect the results of certain x-rays or medical tests. Tell any doctor who treats you that you are using Pylera.

Store at room temperature away from moisture and heat. If you use the 10-day Pylera package, keep each capsule in the blister pack until you are ready to take a dose.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

If you miss more than 4 doses, call your doctor for instructions.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Pylera?

While taking Pylera and for 3 days after your last dose: Do not drink alcohol or consume foods, medicines, or other products that contain alcohol or propylene glycol. You may have unpleasant effects such as headaches, nausea, vomiting, stomach cramps, and warmth or tingling under your skin.

Avoid taking Pylera at the same time you consume milk or other dairy products, or take multivitamins, mineral supplements, or antacids. These products can make it harder for your body to absorb the medicine.

Antibiotic medicines can cause diarrhea. Tell your doctor if you have diarrhea that is watery or bloody.

Pylera could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of Pylera?

Stop taking Pylera and get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • dizziness, problems with speech or coordination;
  • fever, neck stiffness, increased sensitivity to light, nausea, vomiting.
  • a seizure;
  • vaginal itching or discharge;
  • numbness or tingling in your arms and legs; or
  • increased pressure inside the skull --severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

If you have Cockayne syndrome, stop taking Pylera and call your doctor right away if you have signs of liver problems such as stomach pain, nausea, clay-colored stools, or yellowing of your skin or eyes.

Pylera may cause your tongue to become darker in color. It may also cause your stools to appear black in color. These are harmless and temporary side effects.

Common side effects may include:

  • diarrhea or other changes in your stools;
  • nausea; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Pylera?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your current medicines. Many drugs can affect Pylera, especially:

  • cimetidine;
  • an antidepressant;
  • asthma medication;
  • busulfan or other cancer medicine;
  • heart or blood pressure medication;
  • lithium or other antipsychotic medicine;
  • medicine to treat malaria, HIV, or other infection;
  • a blood thinner --warfarin, Coumadin, Jantoven; or
  • seizure medicine --phenytoin or phenobarbital.

This list is not complete and many other drugs may affect Pylera. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about bismuth subcitrate potassium, metronidazole, and tetracycline (Pylera).

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2022 Cerner Multum, Inc. Version: 5.01. Revision date: 9/14/2021.

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