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darunavir

Pronunciation: da ROON a veer

Brand: Prezista

Prezista

slide 1 of 3, Prezista,

600 mg, oval, orange, imprinted with 600MG, TMC

 Image of Prezista
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Prezista

slide 2 of 3, Prezista,

150 mg, oval, white, imprinted with 150, TMC

 Image of Prezista
slide 2 of 3
    

Prezista

slide 3 of 3, Prezista,

800 mg, oval, red, imprinted with 800, T

 Image of Prezista
slide 3 of 3
    

What is the most important information I should know about darunavir?

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Darunavir can cause serious liver problems. Call your doctor if you have upper stomach pain, loss of appetite, tiredness, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Stop taking this medicine and call your doctor right away if you have a severe skin reaction: fever, burning or redness in your eyes, mouth sores, or a skin rash that spreads and causes blistering and peeling.

What is darunavir?

Darunavir is a protease (PRO-tee-ayz) inhibitor antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Darunavir is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Darunavir is not a cure for HIV or AIDS.

Darunavir may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking darunavir?

You should not take this medicine if you are allergic to darunavir or ritonavir (Norvir, Kaletra), or if you have severe liver disease.

Some medicines can cause unwanted or dangerous effects when used with darunavir. Your doctor may change your treatment plan if you also use:

  • alfuzosin;
  • cisapride;
  • colchicine (in people with liver or kidney disease);
  • dronedarone;
  • elbasvir and grazoprevir;
  • lovastatin or simvastatin;
  • pimozide, lurasidone;
  • ranolazine;
  • rifampin;
  • sildenafil (Revatio, for pulmonary arterial hypertension);
  • St. John's wort;
  • triazolam or oral midazolam; or
  • ergot medicines--dihydroergotamine, ergotamine, methylergonovine.

Tell your doctor if you have ever had:

  • liver disease (especially hepatitis B or C);
  • diabetes;
  • a bleeding disorder such as hemophilia; or
  • an allergy to sulfa drugs.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Darunavir can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Darunavir and ritonavir should not be given to a child younger than 3 years old, or a child who weighs less than 22 pounds.

How should I take darunavir?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Darunavir must be taken together with another medication called ritonavir. Use the medicine exactly as directed.

Darunavir works best if you take it with food. Take darunavir and ritonavir together at the same time every day.

Swallow the darunavir tablet whole and do not crush, chew, or break it.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

You will need frequent medical tests.

Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Always take darunavir and ritonavir together.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking darunavir?

If you also take didanosine (Videx), take it 1 hour before or 2 hours after you take darunavir.

Taking this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of darunavir?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • the first sign of any skin rash, no matter how mild;
  • high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor; or
  • signs of liver or pancreas problems --loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Darunavir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

  • signs of a new infection --fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common side effects may include:

  • nausea, vomiting, diarrhea, stomach pain;
  • headache;
  • rash; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect darunavir?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect darunavir, and some drugs should not be used at the same time. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about darunavir.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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