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desloratadine and pseudoephedrine

Pronunciation: DES loe RAT a deen and SOO doe ee FED rin

Brand: Clarinex-D 12 Hour, Clarinex-D 24 Hour

Clarinex-D 12 Hour

slide 1 of 2, Clarinex-D 12 Hour,

2.5 mg-120 mg, oval, blue/white, imprinted with D12

 Image of Clarinex-D 12 Hour
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Clarinex-D 24 Hour

slide 2 of 2, Clarinex-D 24 Hour,

5 mg-240 mg, oval, blue, imprinted with D 24

 Image of Clarinex-D 24 Hour
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What is the most important information I should know about desloratadine and pseudoephedrine?

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

What is desloratadine and pseudoephedrine?

Desloratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Desloratadine and pseudoephedrine is a combination medicine used to treat sneezing, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

This medicine is for adults and children who are at least 12 years old.

Desloratadine and pseudoephedrine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking desloratadine and pseudoephedrine?

You should not use this medicine if you are allergic to desloratadine, loratadine (Claritin), or pseudoephedrine, or if you have:

  • narrow-angle glaucoma;
  • severe coronary artery disease (clogged arteries);
  • uncontrolled high blood pressure; or
  • bladder obstruction or other urination problems.

Do not use desloratadine and pseudoephedrine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have ever had:

  • kidney disease;
  • glaucoma;
  • heart disease or high blood pressure;
  • diabetes;
  • thyroid disorder; or
  • an enlarged prostate.

Desloratadine and pseudoephedrine should not be given to a child younger than 12 years old.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast feed while using desloratadine and pseudoephedrine.

How should I take desloratadine and pseudoephedrine?

Use exactly as directed on the label, or as prescribed by your doctor. Cold or allergy medicine is only for short-term use until your symptoms clear up.

Swallow the tablet whole and do not crush, chew, or break it.

Call your doctor if your symptoms do not improve after 7 days, or if you have a fever.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a daily dosing schedule. If you are on a schedule, take the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause anxiety, trouble sleeping, headache, vomiting, thirst, muscle weakness, fast or pounding heartbeats, hallucinations, shallow breathing, or a seizure.

What should I avoid while taking desloratadine and pseudoephedrine?

This medicine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Drinking alcohol with this medicine can cause side effects.

Ask a doctor or pharmacist before using over-the-counter medicines. They may contain ingredients similar to desloratadine and pseudoephedrine.

What are the possible side effects of desloratadine and pseudoephedrine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • tremors;
  • severe weakness;
  • irregular heartbeats;
  • a seizure; or
  • a severe skin reaction --fever, skin redness, small pimples.

Common side effects may include:

  • drowsiness, dizziness;
  • headache
  • nausea, loss of appetite;
  • sleep problems (insomnia); or
  • dry mouth, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect desloratadine and pseudoephedrine?

Using desloratadine and pseudoephedrine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Ask a doctor or pharmacist before using desloratadine and pseudoephedrine with any other medications, especially:

  • any other cold or allergy medicine;
  • ketoconazole;
  • reserpine;
  • an antibiotic --azithromycin (Zithromax, Z-Pak), erythromycin; or
  • heart or blood pressure medication --digoxin, digitalis, methyldopa.

This list is not complete. Other drugs may affect desloratadine and pseudoephedrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about desloratadine and pseudoephedrine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 4.01. Revision date: 3/2/2018.

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