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eplerenone

Pronunciation: ep LER e none

Brand: Inspra

Inspra

slide 1 of 8, Inspra,

25 mg, diamond, yellow, imprinted with Pfizer, NSR 25

 Image of Inspra
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Inspra

slide 2 of 8, Inspra,

50 mg, diamond, yellow, imprinted with Pfizer, NSR 50

 Image of Inspra
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Eplerenone

slide 3 of 8, Eplerenone,

25 mg, diamond, yellow, imprinted with G, 25mg

 Image of Eplerenone
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Eplerenone

slide 4 of 8, Eplerenone,

50 mg, diamond, yellow, imprinted with G, 50mg

 Image of Eplerenone
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Eplerenone

slide 5 of 8, Eplerenone,

25 mg, round, yellow, imprinted with APO, EP 25

 Image of Eplerenone
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Eplerenone

slide 6 of 8, Eplerenone,

50 mg, round, yellow, imprinted with APO, EP 50

 Image of Eplerenone
slide 6 of 8
    

Inspra

slide 7 of 8, Inspra,

25 mg, diamond, yellow, imprinted with Pfizer, NSR 25

 Image of Inspra
slide 7 of 8
    

Inspra

slide 8 of 8, Inspra,

50 mg, diamond, yellow, imprinted with Pfizer, NSR 50

 Image of Inspra
slide 8 of 8
    

What is the most important information I should know about eplerenone?

You may not be able to take this medicine if you have severe kidney disease, high potassium levels in your blood, or type 2 diabetes with increased levels of albumin (a protein) in your urine.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What is eplerenone?

Eplerenone is used to lower the risk of death from heart failure after a heart attack.

Eplerenone is also used to treat high blood pressure (hypertension).

Eplerenone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking eplerenone?

You may not be able to take this medicine if you are allergic to eplerenone, or if you have:

  • high potassium levels in your blood (hyperkalemia);
  • severe kidney disease; or
  • type 2 diabetes with increased levels of albumin (a protein) in your urine.

Some medicines can cause unwanted or dangerous effects when used with eplerenone. Your doctor may change your treatment plan if you also use:

  • nefazodone;
  • a potassium supplement;
  • an antibiotic --clarithromycin, telithromycin;
  • antifungal medicine --itraconazole, ketoconazole;
  • a diuretic or "water pill" --amiloride, spironolactone, triamterene; or
  • antiviral medicine to treat HIV/AIDS --indinavir, nelfinavir, ritonavir, saquinavir.

Tell your doctor if you have ever had:

  • kidney disease;
  • diabetes;
  • liver disease;
  • high cholesterol or triglycerides; or
  • if you take other heart or blood pressure medications.

Tell your doctor if you are pregnant or breastfeeding.

It is not known whether eplerenone will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). Heart failure can get worse during pregnancy and may cause complications such as premature birth. The benefit of treating hypertension or heart failure may outweigh any risks to the baby.

This medicine may affect fertility (ability to have children) in men.

How should I take eplerenone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Eplerenone may be taken with or without food.

You may need blood tests, and your blood pressure will need to be checked often.

If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking eplerenone?

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

What are the possible side effects of this drug?

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • diarrhea, vomiting;
  • little or no urination;
  • fast or irregular heartbeats;
  • trouble breathing;
  • swelling in your feet or lower legs; or
  • high potassium --nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.

Common side effects may include:

  • high potassium;
  • headache; or
  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect eplerenone?

Tell your doctor about all your current medicines. Many drugs can affect eplerenone, especially:

  • lithium;
  • heart or blood pressure medicine --amiodarone, benazepril, diltiazem, dronedarone, enalapril, lidocaine, lisinopril, olmesartan, valsartan, verapamil, and others; or;
  • NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete and many other drugs may affect eplerenone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about eplerenone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 7.01. Revision date: 3/18/2019.

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