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pegfilgrastim

Pronunciation: PEG fil GRAS tim

Brand: Fulphila, Neulasta, Neulasta Onpro Kit

What is the most important information I should know about pegfilgrastim?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is pegfilgrastim?

Pegfilgrastim is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

Pegfilgrastim is used to prevent neutropenia (a lack of certain white blood cells) that is caused by receiving chemotherapy.

Pegfilgrastim may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using pegfilgrastim?

You should not use this medicine if you are allergic to pegfilgrastim or filgrastim (Neupogen).

Tell your doctor if you have ever had:

  • sickle cell disorder;
  • kidney disease;
  • chronic myeloid leukemia;
  • radiation treatment;
  • myelodysplasia (also called "preleukemia"); or
  • a latex allergy.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of pegfilgrastim on the baby.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I use pegfilgrastim?

Pegfilgrastim is injected under the skin, usually once per chemotherapy cycle. A healthcare provider may teach you how to properly use the medication by yourself.

Pegfilgrastim should not be given within 14 days before or 24 hours after you receive chemotherapy.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use pegfilgrastim if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Do not shake the prefilled syringe or you may ruin the medicine.

The Neulasta Onpro Injector is a special device placed on the skin that delivers your pegfilgrastim dose at a specific time. You will need to wear the device for 27 hours before the dose begins. The timed dose will then be released from the device slowly over a 45-minute period.

While wearing Neulasta Onpro, you or a caregiver will need to check the device to make sure it is working properly.

Each prefilled syringe or Onpro Injector is for one use only. Throw it away after one use, even if there is still medicine left inside.

You may need frequent medical tests to help your doctor determine how long to treat you with pegfilgrastim.

Store pegfilgrastim in its original package in the refrigerator, protected from light. Do not freeze.

Take a prefilled syringe out of the refrigerator and let it reach room temperature for 30 minutes before injecting your dose.

Throw away any unused Fulphila syringe that has been left at room temperature for longer than 72 hours, or any Neulasta syringe that has been left at room temperature for longer than 48 hours.

Keep Neulasta Onpro refrigerated until you are ready to wear it. Do not use an Onpro device that has been left out of a refrigerator for longer than 12 hours.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss an injection, or if you have a problem with the Neulasta Onpro device.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using pegfilgrastim?

When using Neulasta Onpro: Avoid traveling, driving, or operating machinery while wearing the device.

What are the possible side effects of pegfilgrastim?

Get emergency medical help if you have signs of an allergic reaction: hives, skin rash, flushing (warmth, redness, or tingly feeling); wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.

Capillary leak syndrome is a rare but serious side effect of pegfilgrastim. Call your doctor right away if you have signs of this condition, which may include: decreased urination, tiredness, dizziness or light-headed feeling, trouble breathing, and sudden swelling, puffiness, or feeling of fullness.

Call your doctor at once if you have:

  • fever, tiredness, stomach pain, back pain;
  • sudden or severe pain in your left upper stomach spreading up to your shoulder;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • rapid breathing, feeling short of breath, pain while breathing;
  • bruising, swelling, or a hard lump where the medicine was injected; or
  • kidney problems --little or no urination, pink or dark urine, swelling in your feet or ankles.

Common side effects may include:

  • fever;
  • diarrhea;
  • shortness of breath;
  • rash, hair loss;
  • numbness;
  • nosebleeds;
  • headache, bone pain, muscle aches; or
  • pain in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pegfilgrastim?

Other drugs may affect pegfilgrastim, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about pegfilgrastim.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 4.01. Revision date: 9/4/2018.

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