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doxylamine and pyridoxine

Pronunciation: dox IL a meen and PIR i DOX een

Brand: Bonjesta, Diclegis

Diclegis

slide 1 of 1, Diclegis,

10 mg-10 mg, round, white, imprinted with LOGO

 Image of Diclegis
slide 1 of 1
    

What is the most important information I should know about doxylamine and pyridoxine?

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

What is doxylamine and pyridoxine?

Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body.

Pyridoxine is a form of vitamin B (B6).

Doxylamine and pyridoxine is a combination medicine used to treat nausea and vomiting during pregnancy, sometimes called morning sickness.

Doxylamine and pyridoxine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking doxylamine and pyridoxine?

Do not use doxylamine and pyridoxine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to doxylamine or pyridoxine, or to other antihistamines such as Benadryl or Dramamine.

Tell your doctor if you have ever had:

  • asthma or other breathing disorder;
  • glaucoma, increased pressure inside your eye;
  • blockage in your digestive tract (stomach or intestines);
  • a stomach ulcer; or
  • bladder obstruction or other urination problems.

You should not breast-feed while using doxylamine and pyridoxine.

Doxylamine and pyridoxine is not approved for use by anyone younger than 18 years old.

How should I take doxylamine and pyridoxine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take this medicine on an empty stomach with a full glass of water.

Doxylamine and pyridoxine is either taken at bedtime, or at bedtime and in the morning. Follow your doctor's dosing instructions very carefully.

Swallow the capsule or tablet whole and do not crush, chew, or break it.

Call your doctor if your symptoms do not improve, or if they get worse. Severe or ongoing vomiting can cause you to become dehydrated which can lead to serious medical problems.

Store at room temperature away from moisture and heat.

Keep the pills in their original container, along with the packet or canister of moisture-absorbing preservative.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Do not take more than 2 tablets or capsules in 24 hours.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, extreme drowsiness or dizziness, confusion, restless feeling, dilated pupils, rapid heartbeats, seizure (convulsions), or muscle pain or weakness with fever and dark colored urine.

What should I avoid while taking doxylamine and pyridoxine?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid drinking alcohol. It can increase drowsiness caused by doxylamine and pyridoxine.

Do not take any medicine without your doctor's advice while you are pregnant.

What are the possible side effects of doxylamine and pyridoxine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include:

  • drowsiness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect doxylamine and pyridoxine?

Using doxylamine and pyridoxine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may affect doxylamine and pyridoxine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about doxylamine and pyridoxine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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