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saquinavir

Pronunciation: sa KWIN a veer

Brand: Invirase

Invirase 500 mg

slide 1 of 1, Invirase 500 mg,

oblong, orange, imprinted with SQV 500, ROCHE

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What is the most important information I should know about saquinavir?

You should not take saquinavir if you have certain serious heart problems, severe liver disease, low blood levels of potassium or magnesium, or if you also take medicine that contains cobicistat.

Saquinavir must be taken together with another medicine called ritonavir.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Saquinavir can cause serious heart rhythm problems. Call your doctor at once if you have fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness.

What is saquinavir?

Saquinavir is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Saquinavir is used together with ritonavir to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Neither saquinavir nor ritonavir will not cure HIV or AIDS.

Saquinavir may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking saquinavir?

You should not take saquinavir if you are allergic to it, or if you have:

  • a serious heart condition called "AV block" (unless you have a pacemaker);
  • long QT syndrome (in you or a family member);
  • severe liver disease;
  • low levels of potassium or magnesium in your blood; or
  • if you also take medicine that contains cobicistat.

Life-threatening side effects may occur if you take saquinavir and ritonavir with:

  • other HIV medicines --atazanavir, rilpivirine;
  • alfuzosin;
  • oral midazolam, or triazolam;
  • sildenafil (Revatio, for treating pulmonary arterial hypertension);
  • tacrolimus;
  • trazodone;
  • anti-psychotic medication --chlorpromazine, clozapine, haloperidol, lurasidone, mesoridazine, pimozide, thioridazine, ziprasidone;
  • cancer medicine --dasatinib, sunitinib;
  • certain anti-infective medicines --clarithromycin, dapsone, erythromycin, halofantrine, pentamidine, rifampin;
  • cholesterol medication --lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin);
  • ergot medicine --dihydroergotamine, ergotamine, ergonovine, methylergonovine; or
  • heart rhythm medicine --amiodarone, disopyramide, dofetilide, flecainide, lidocaine, propafenone, or quinidine.

Tell your doctor if you have ever had:

  • heart disease;
  • liver disease (including hepatitis B or C);
  • hemophilia (a bleeding disorder);
  • diabetes; or
  • alcoholism.

HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of saquinavir on the baby.

Saquinavir can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Saquinavir is not approved for use by anyone younger than 16 years old.

How should I take saquinavir?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Saquinavir must be taken together with ritonavir and it should not be used alone.

Take your medicine with food or within 2 hours after eating a full meal.

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of jam or sugar syrup (use sorbitol if you are diabetic). Stir for about a minute and allow it to reach room temperature. Swallow the mixture right away without chewing. Do not save it for later use.

You will need frequent medical tests.

HIV is often treated with a combination of drugs. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely. Skipping doses may increase the risk of your virus becoming resistant to antiviral medicine.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking saquinavir?

Taking this medicine will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of saquinavir?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • cough with mucus, chest pain, wheezing, and shortness of breath;
  • heart rhythm problems --fast or pounding heartbeats, fluttering in your chest, shortness of breath, sudden dizziness (like you might pass out);
  • high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor, headache, blurred vision; or
  • liver problems --upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Saquinavir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

  • signs of a new infection --fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common side effects may include:

  • nausea, vomiting, diarrhea, stomach pain;
  • tired feeling; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect saquinavir?

Many drugs can interact with saquinavir or ritonavir, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about saquinavir.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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