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dornase alfa (inhalation)

Pronunciation: DOOR nase AL fa

Brand: Pulmozyme

What is the most important information I should know about dornase alfa?

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What is dornase alfa?

Dornase alfa is used in people with cystic fibrosis to thin mucus in the airways. This may help improve lung function and lower the risk of infections.

Dornase alfa may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using dornase alfa?

You should not use this medicine if you are allergic to dornase alfa or other Chinese Hamster Ovary cell products.

Do not give this medicine to a child without medical advice.

Tell your doctor if you are pregnant or breastfeeding.

How should I use dornase alfa?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Use dornase alfa regularly to get the most benefit.

Read and follow all Instructions for Use. Ask your doctor or pharmacist if you need help.

To use the solution with most nebulizers:

  • Pour the medicine into the nebulizer chamber. Attach the mouthpiece or face mask, then attach the chamber to the compressor. Sit upright and place the mouthpiece into your mouth or put on the face mask. Turn on the compressor.
  • Breathe slowly and evenly until there is no more mist and the drug chamber is empty.
  • Clean the nebulizer after each use. On certain nebulizer systems, you may need to change the handset after 90 uses. Follow the directions that came with your nebulizer.

Do not dilute or mix dornase alfa with any other drugs in the nebulizer.

Tell the doctor if your child has trouble breathing in or out while using the nebulizer.

Each ampule is for one use only. Throw it away after one use, even if there is still medicine left inside.

Store dornase alfa ampules in the refrigerator, protected from light. Keep unused ampules in the protective foil pouch.

If needed, you may store an ampule at room temperature for short periods of time (up to a total of 60 hours). Protect from heat and light.

Call your pharmacist if the medicine looks cloudy or has changed colors.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Overdose is unlikely when used as directed, and is not expected to cause harmful effects.

What should I avoid while using dornase alfa?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of dornase alfa?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have worsened breathing problems.

Common side effects may include:

  • sore throat;
  • chest pain, trouble breathing;
  • changes in the sound of your voice;
  • rash;
  • eye redness; or
  • fever.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dornase alfa?

Other drugs may affect dornase alfa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your pharmacist can provide more information about dornase alfa.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2022 Cerner Multum, Inc. Version: 4.01. Revision date: 7/8/2021.

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