WellSpan Home

ifosfamide

Pronunciation: eye FOS fah mide

Brand: Ifex

What is the most important information I should know about ifosfamide?

You should not receive ifosfamide if you have a medical condition that causes urination problems (such as an enlarged prostate).

Ifosfamide affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising.

Ifosfamide can affect your kidneys or nervous system. Call your doctor at once if you have urination problems, blood in your urine, problems with your hearing or vision, unusual thoughts or behavior, hallucinations, or a seizure.

What is ifosfamide?

Ifosfamide is used with other medicines to treat testicular cancer in men.

Ifosfamide is usually given after other treatments have failed.

Ifosfamide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving ifosfamide?

You should not be treated with ifosfamide if you are allergic to it, or if you have a medical condition that causes urination problems (such as an enlarged prostate).

Tell your doctor if you have ever had:

  • kidney disease;
  • heart disease;
  • a bladder infection;
  • treatment with busulfan; or
  • radiation treatment of your bladder.

Using ifosfamide may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk.

Ifosfamide can cause birth defects if a woman is exposed to it during pregnancy.

Use effective birth control to prevent pregnancy, whether you are a man or a woman. Ifosfamide use by either parent may cause birth defects. Keep using birth control for at least 6 months after treatment.

This medication may affect fertility (your ability to have children), whether you are a man or a woman. Some women using ifosfamide have stopped having periods, or started having symptoms of early menopause.

A woman receiving ifosfamide should not breast-feed.

How is ifosfamide given?

Your doctor will perform blood and urine tests to make sure you do not have conditions that would prevent you from safely using this medicine.

Ifosfamide is given as an infusion into a vein. A healthcare provider will give you this injection.

If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.

Ifosfamide is given in a 21-day treatment cycle, but you will receive the medicine only during the first 5 days of each cycle. Your doctor will determine how many cycles you should receive.

Drink plenty of liquids while you are taking ifosfamide.

Your blood will need to be tested often. Your heart, kidney function, liver function, or nerve and muscle function may also need to be checked. Your cancer treatments may be delayed based on the results.

Ifosfamide can have long lasting effects on your body. You may also need medical tests for a short time after your last dose.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your ifosfamide injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving ifosfamide?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol can increase certain side effects of ifosfamide, especially nausea and vomiting.

Grapefruit may interact with ifosfamide and lead to unwanted side effects. Avoid the use of grapefruit products.

Do not receive a "live" vaccine while using ifosfamide, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

What are the possible side effects of ifosfamide?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

  • fever, chills, flu symptoms;
  • mouth and throat ulcers;
  • skin sores, pale skin, cold hands and feet;
  • easy bruising, unusual bleeding;
  • rapid heart rate, shallow breathing; or
  • feeling light-headed or short of breath.

Call your doctor at once if you have any of these side effects:

  • confusion, unusual thoughts or behavior, hallucinations, seizure (convulsions);
  • little or no urination, painful or difficult urination, blood in your urine;
  • loss of bladder control;
  • a seizure;
  • muscle movements you cannot control;
  • problems with your hearing or vision, ringing in your ears;
  • sudden chest pain, wheezing, dry cough;
  • dark urine, jaundice (yellowing of the skin or eyes); or
  • a wound that will not heal.

Common side effects may include:

  • nausea and vomiting;
  • confusion, vision problems, thinking problems;
  • numbness, tingling, burning pain;
  • infections;
  • urination problems; or
  • hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ifosfamide?

Using ifosfamide with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect ifosfamide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about ifosfamide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 3.02. Revision date: 11/28/2018.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.

Are you sure you would like to cancel?

All information will be lost.

Yes No ×

About the provider search

This search will provide you with WellSpan Medical Group and Northern Lancaster County (Ephrata) Medical Group primary care physicians and specialists. If we don’t have a WellSpan Medical Group physician to meet your criteria, the search will expand to include community physicians who partner with WellSpan Medical Group physicians through the WellSpan Provider Network or provide care to patients on the Medical Staffs of WellSpan’s Hospitals.

×

Schedule Your Next Appointment Online with MyWellSpan

Use your MyWellSpan patient portal any time to view available appointments, and pick the date and time that best suits your schedule.

Go to MyWellSpan

New to this practice?

If you don't have a WellSpan primary care provider and would like to schedule a new patient appointment with a provider who is accepting patients, just log into your MyWellSpan account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to see the offices that are accepting new patients in relation to your zip code. If you are not enrolled in MyWellSpan, go to https://my.wellspan.org, call 1-866-638-1842 or speak with a member of the staff at a participating facility to sign up. New patient scheduling not available at all practices/programs.

Already a patient at this practice?

If you already have a relationship with a WellSpan practice, simply log into your account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to schedule an appointment with any provider or practice that already counts you as a patient. Online scheduling varies by practice/program.

×