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glyburide

Pronunciation: GLYE bue ride

Brand: DiaBeta, Glynase PresTab

GlyBURIDE 1.25 mg-GG

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Glyburide 1.25 mg-GRE

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round, white, imprinted with G 3725

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Glyburide 1.25 mg-M-TEV

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round, white, imprinted with N 342, 1.25

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Glyburide 2.5 mg-COP

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oblong, pink, imprinted with GLYBUR, 433 433

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Glyburide 2.5 mg-GRE

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round, pink, imprinted with G 3726

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Glyburide 2.5 mg-M-TEV

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round, white, imprinted with N 343, 2.5

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Glyburide 2.5 mg-NVP

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round, peach, imprinted with N 343, 2.5

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Glyburide 3 mg-MYL

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oblong, yellow, imprinted with M 125

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Glyburide 5 mg -COP

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oblong, blue, imprinted with GLYBUR, 364 364

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Glyburide 5 mg-D-TEV

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oblong, blue, imprinted with GLYBUR

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GlyBURIDE 5 mg-GG

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Glyburide 5 mg-GRE

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round, blue, imprinted with G 3727

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Glyburide 5 mg-M-TEV

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round, green, imprinted with N 344, 5

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Glyburide 5 mg-NVP

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round, green, imprinted with N 344, 5

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Glyburide Micronized 1.5 mg-STA

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oval, white, imprinted with MOVA, MO3 1.5

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Glyburide Micronized 3 mg-COP

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Glyburide Micronized 3 mg-STA

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oval, blue, imprinted with MOVA, MO4 3.0

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Glyburide Micronized 3 mg-TEV

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oval, blue, imprinted with 3 035, N

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Glynase 3 mg

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oblong, blue, imprinted with PT PT, GLYNASE 3

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Glynase 6 mg

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What is the most important information I should know about glyburide?

You should not use this medicine if you are being treated with bosentan (Tracleer), or if you have diabetic ketoacidosis (call your doctor for treatment). Glyburide is not for treating type 1 diabetes.

What is glyburide?

Glyburide is an oral diabetes medicine that helps control blood sugar levels.

Glyburide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Glyburide is not for treating type 1 diabetes.

Glyburide may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking glyburide?

You should not use glyburide if you are allergic to it, or if:

  • you are being treated with bosentan (Tracleer);
  • you have type 1 diabetes; or
  • you have diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

  • hemolytic anemia (a lack of red blood cells);
  • an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
  • a nerve disorder affecting bodily functions;
  • liver or kidney disease; or
  • an allergy to sulfa drugs.

Before taking glyburide, tell your doctor if you have taken another oral diabetes medicine or used insulin during the past 2 weeks.

Glyburide may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using this medicine if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy.

You should not breast-feed while using this medicine.

How should I take glyburide?

Glyburide is usually taken with breakfast or the first main meal of the day.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

If your doctor changes your brand, strength, or type of glyburide, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of glyburide you receive at the pharmacy.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.

What should I avoid while taking glyburide?

If you also take colesevelam, avoid taking it within 4 hours after you take glyburide.

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Glyburide could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of glyburide?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • dark urine, jaundice (yellowing of the skin or eyes);
  • severe skin rash, redness, or itching;
  • pale skin, easy bruising or bleeding;
  • fever, chills, sore throat, mouth sores; or
  • low levels of sodium in the body --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Older adults may be more likely to have low blood sugar while taking glyburide.

Common side effects may include:

  • low blood sugar;
  • nausea, heartburn, feeling full;
  • muscle or joint pain;
  • blurred vision; or
  • mild rash or skin redness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect glyburide?

Glyburide may not work as well when you use other medicines at the same time. Many other drugs can also affect blood sugar control. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about glyburide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 11.02. Revision date: 2/16/2018.

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