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Multiple myeloma

Multiple myeloma (plasma cell neoplasm) is a rare type of cancer that results in the uncontrolled production of one type of white blood cell (plasma cell) in the bone marrow. The cancer cells can crowd out normal blood cells, causing a reduction in red blood cells (anemia).

The overproduction of plasma cells causes an increase in antibodies. The plasma cells also may cause the bone to break down. The plasma cells can collect in the bone to make small tumors called plasmacytomas.

The most common symptoms of multiple myeloma include night sweats, weight loss, weakness, fatigue, bone pain, pneumonia, numbness, paralysis, or kidney failure. If the bones of the spine are involved, they may collapse. This causes spinal cord compression.

The exact cause of multiple myeloma is not known. It is slightly more common in men than in women. And it is usually diagnosed between the ages of 40 and 70. The disease is very rare before the age of 40.

Multiple myeloma that isn't causing symptoms may not need treatment right away. When symptoms are present, most people will have several types of treatments. These may include:

  • Chemotherapy.
  • Radiation.
  • Steroids.
  • Stem cell transplants.
  • Targeted therapy.

Bone tumors caused by multiple myeloma may be treated with medicines, radiation, and surgery.


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