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Hyperthermia For Cancer Treatment

What is hyperthermia in cancer treatment?

Hyperthermia is heat therapy. Heat has been used for hundreds of years as cancer therapy. Scientists believe that heat may help shrink tumors by damaging cells or depriving them of the substances they need to live. It may also make the cancer cells more sensitive to other cancer treatments like radiation and chemotherapy. There are research studies underway to determine the use and effectiveness of hyperthermia in cancer treatment. Because this treatment is not yet considered standard of care, its use outside the setting of a research trial is uncommon.

How is it used?

Heat can be applied to a very small area, to an organ or limb, or to the whole body. Hyperthermia is usually used with chemotherapy, radiation therapy, and other cancer treatments. The types of hyperthermia are described in the following chart:

Type of hyperthermia

Treatment area

Method of application

Local hyperthermia

Treatment area includes a tumor or other small area.

  • Heat is applied from the outside with high-frequency waves aimed at the tumor.


  • Inside the body a small area may be heated with thin heated wire probes or implanted microwave antennae and radiofrequency electrodes.

Regional hyperthermia

An organ or a limb is treated.

  • Devices that produce high energy are placed over the region to be heated.


  • Some of the blood is removed, heated, and then pumped into the region to be heated. The process is called perfusion.

Whole-body hyperthermia

The whole body is treated.

  • Warm water blankets

  • Inductive coils (similar to the coils in an electric blanket)

  • Thermal room or chambers

Are there any side effects?

Side effects may include skin discomfort or local pain. Hyperthermia can also cause blisters and sometimes burns, but generally these heal quickly. Local hyperthermia can cause pain at the site, infection, blood clots, burns, and damage to the muscles, skin, and nerves in the treated area. Whole body hyperthermia can cause diarrhea, nausea, and vomiting. Please note that improved technology, research, and treatment experience have resulted in fewer side effects. Most side effects people experience are short-term and not serious. 

Hyperthermia For Cancer Treatment - WellSpan Health

Online Medical Reviewer: MMI board-certified, academically affiliated clinician
Online Medical Reviewer: Welch, Annette, MNS, OCN
Last Review Date: 2014-02-01T00:00:00
Last Modified Date: 2014-03-17T00:00:00
Posting Date: 2008-11-30T00:00:00
Published Date: 2014-03-17T00:00:00
Last Review Date: 2012-06-05T00:00:00
© 2015 WellSpan Health. All Rights Reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

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